The team will be without Antonio Brown, Sean Davis and Vince Williams.
Brown missed practice time this week with a knee injury, something that had him appear on the injury report beginning on Thursday.
"Coming out of the (Saints) game AB was experiencing some knee discomfort," said Coach Mike Tomlin. "I gave him a vet day on Wednesday. He got in here (Thursday) and didn't feel comfortable enough to do it. We sent him for tests (Friday)."
Davis, who missed two days of practice with a quadriceps injury, practiced on Friday but also isn't playing. Williams missed practice all week with a toe injury and was listed as doubtful going into the game.
James Conner, who practiced all week, is active today. Conner had missed the last three games, something he said earlier in the week was tough for him. In his absence Jaylen Samuels stepped up big, and the two will be used against the Bengals today.
"We're excited to get James back," said Tomlin. "He is a big-time component of our play. We also have been pleased by the contributions of No. 38. We are going to utilize both guys. James hasn't played in a while. Football conditioning and things of that nature are a factor. We are going to utilize both guys and let the flow of the game dictate it."
Also inactive are Mason Rudolph, Zach Banner, Ola Adeniyi and L.T. Walton.
The full list of inactives is below.
No. 2 QB Mason Rudolph
No. 21 S Sean Davis
No. 72 OT Zach Banner
No. 84 WR Antonio Brown
No. 92 LB Olasunkanmi Adeniyi
No. 96 DE L.T. Walton
No. 98 LB Vince Williams
No. 11 WR Hunter Sharp
No. 29 CB Tony McRae
No. 34 HB Quinton Flowers
No. 55 OLB Vontaze Burfict
No. 70 OT Cedric Ogbuehi
No. 76 OT Kent Perkins
No. 88 TE Jordan Franks