Historic Lambeau Field turned into a venue in which recent history was repeated for the Steelers.
The offense started fast but was unable to dent the end zone again until just 4:04 remained in the game and the Steelers were beaten by the Packers, 27-17, in Green Bay, Wis.
The Steelers lost their third straight game and fell to 1-3.
The Packers won their third straight and improved to 3-1.
Quarterback Ben Roethlisberger went 26-for-40 passing for 232 yards with one touchdown and one interception.
Roethlisberger became the eighth player in NFL history to throw 400 career touchdown passes and passed Dan Marino ( 61,361) for sixth place on the NFL's all-time passing yards list (61,381).
Running back Najee Harris' 1-yard touchdown run and kicker Chris Boswell's extra point accounted for the final margin with 4:04 left in the fourth quarter.
The Steelers' defense held the Packers to a field goal on the first possession of the second half, when the Packers drove from their 25-yard line to the Steelers' 5. From there, running back Aaron Jones lost 3 yards, quarterback Aaron Rodgers was sacked by outside linebacker T.J. Watt for a loss of 3 and Rodgers threw incomplete into the end zone.
Kicker Mason Crosby's 29-yard field goal upped Green Bay's lead to 20-10 with 9:31 left in the third quarter.
The Packers were more efficient the next time opportunity knocked.
They moved 40 yards on four plays in 2:15 after a 20-yard punt had established possession at the Steelers' 40. Running back AJ Dillion burst for 25 yards to the Steelers' 1 and Rodgers found wide receiver Randall Cobb just inside the pylon on a bootleg right. Crosby's extra point made it 27-10 Packers with 4:46 left in the third.
The Packers took a 17-10 lead into the locker room at halftime after a blocked 31-yard field goal attempt and return for a touchdown by free safety Minkah Fitzpatrick was nullified by an offside penalty against cornerback Joe Haden.
Game action photos from the Steelers' Week 4 game against the Green Bay Packers at Lambeau Field
Crosby connected on a second attempt, this one from 26 yards away, and upped the Packers' advantage to seven with five seconds left in the second quarter. Green Bay's scoring drive covered 76 yards on 13 plays in 5:36.
The Packers took a 14-7 lead on a 23-yard catch-and-run touchdown by Cobb and a Crosby extra point with 10:55 left in the second.
Green Bay gained possession on a turnover created when defensive end Kingsley Keke knocked the ball from Roethlisberger's grasp and the fumble was recovered by nose tackle Kenny Clark at the Steelers' 23. The Packers overcame a 10-yard penalty for an illegal block on the first play of what became a four-play, 23-yard touchdown drive in 1:33.
The Steelers closed to within 14-10 on a 52-yard field goal by kicker Chris Boswell with 5:41 remaining prior to halftime. The 10-play, 41-yard drive in 5:14 might have resulted in a touchdown, but Roethlisberger over-threw wide receiver JuJu Smith-Schuster at the Green Bay 5 on first-and-10 from the Packers' 32.
The Steelers struck first on a free-play connection from Roethlisberger to wide receiver Diontae Johnson that went for a 45-yard touchdown. The Packers had jumped offside on third-and-4 from the Green Bay 45 and the Steelers took advantage by taking a shot deep. Boswell's extra point gave the Steelers a 7-0 lead with 10:04 left in the first quarter.
The eight-play, 75-yard drive in 4:56 produced the Steelers' first first-quarter points and first first-possession points of the season.
The Steelers extended the drive when Harris gained 2 yards on third-and-1 from the Steelers' 47.
The Packers countered with a 13-play, 64-yard drive in 4:51 on their second possession.
Rodgers finished it with a 4-yard scramble for a touchdown. Green Bay converted a third-and-3, a third-and-6 and a third-and-4 on the way to the end zone. Crosby's extra point tied the game at 7-7 with 13:22 left in the second quarter.